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Natural Carrier-Free Self-Assembled Binary Polyphenol Nanoparticles Remodel the Gut Microenvironment for Inflammatory Bowel Disease Prevention
Developing biocompatible, multi-target therapeutics remains a critical challenge in the management of inflammatory bowel disease (IBD). …
Qiwen Xie, Huan Xu, Xiaoming Yang, Ying Chen, Zhenjiang Zech Xu
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Porphyromonas Gingivalis Induces Intestinal Inflammation through Gingipain-Dependent Gut Microbiome Dysbiosis
Background Porphyromonas gingivalis (Pg), a key pathogen in periodontitis, is implicated in various systemic diseases such as …
Ming Li, Jiyun Cui, Ru Qu, Rulong Liu, Yifan Sun, Ping Li, Juan Liu, Adrian Low, Xiaochang Huang, Fei Gan, Zhenjiang Zech Xu
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Propylparaben Induces Immunotoxicity in Zebrafish via Oxidative Stress and Gut Microbiota-Immune Axis Dysregulation
Propylparaben (PP), a widely used preservative, has an unclear immunotoxicity profile. In this study, zebrafish embryos were exposed to …
Yong Huang, Jing Hu, Huan Xu, Runhao Zhu, Liting Liu, Xiaomei Chen, Yifan Sun, Yuwei Zhao, Yebing Zhong, Bo Cheng, Xiaochang Huang, Huiqiang Lu, Zhenjiang Zech Xu
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Scikit-Bio: A Fundamental Python Library for Biological Omic Data Analysis
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Dietary Nisin Exacerbates Diabetic Vascular Complications through Gut Microbiota Modulation and NF-κB Signaling
Diabetic vascular complications (DVCs) are a major cause of morbidity in diabetes, with gut microbiota dysbiosis emerging as an …
Liting Liu, Yong Huang, Huan Xu, Yifan Sun, Zhenjiang Zech Xu, Xiaochang Huang
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High-Resolution Microbiome Analysis of Host-Rich Samples Using 2bRAD-M without Host Depletion
Characterizing human microbiota in host-dominated samples is crucial for understanding host-microbe interactions, yet is challenged by …
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Decoding Oral Leukoplakia: Microbiome Dysbiosis and Inflammatory Dynamics Unveiled in a Rat Model
Introduction: Oral leukoplakia (OLK) is an oral precancerous lesion associated with oral microbiome dysbiosis and systemic …
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Survival and Safety Evaluation of Bifidobacterium Longum Subsp. Longum ZS-8 in Healthy Adults, Determined Using PMAxx-qPCR and Amplicon Sequencing
Species-level quantitative PCR (qPCR) provides in-depth knowledge of oral probiotics in the human gastrointestinal tract (GIT). …
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RNA–Ligand Interaction Scoring via Data Perturbation and Augmentation Modeling
Despite recent advances in RNA-targeting drug discovery, the development of data-driven deep learning models remains challenging owing …
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Metatranscriptomics Uncovers Diurnal Functional Shifts in Bacterial Transgenes with Profound Metabolic Effects
Diurnal rhythmicity in the gut maintains gut integrity, circadian rhythms, and metabolic homeostasis. However, existing studies focus …
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