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Systematic Analyses Uncover Robust Salivary Microbial Signatures and Host-Microbiome Perturbations in Oral Squamous Cell Carcinoma
Oral squamous cell carcinoma (OSCC) is a prevalent malignancy in the oral-maxillofacial region with a poor prognosis. Oral microbiomes …
Zewen Han, Yichen Hu, Xin Lin, Hongyu Cheng, Biao Dong, Xuan Liu, Buling Wu, Zhenjiang Zech Xu
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Impacts of Food Additives on Gut Microbiota and Host Health
The rapidly expanding food industry necessitates the use of food additives to achieve specific purposes. However, this raises new …
Ping Li, Ru Qu, Ming Li, Ping Sheng, Liang Jin, Xiaochang Huang, Zhenjiang Zech Xu
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Epimedium Polysaccharides Mitigates emphPorphyromonasemph Gingivalis-Exacerbated Intestinal Inflammation by Suppressing the Th17 Pathway and Modulating the Gut Microbiota
This study aimed to investigate the potential alleviating effect of Epimedium polysaccharide (EP) on intestinal inflammation aggravated …
Ming Li, Ru Qu, Ping Li, Xuan Mo, Juan Liu, Biao Dong, Liting Liu, Zhenjiang Zech Xu
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Screening of Lactic Acid Bacteria from Freshwater Fish Intestines and Their Effects on Growth, Immunity, and Disease Resistance in Zebrafish
This study aims to isolate the freshwater fish–derived potential probiotics and evaluate their beneficial effects on the growth, immune …
Huiyu Zhang, Qiwen Zhang, Yan Li, Zhenjiang Zech Xu, Xiaochang Huang
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A Conserved Interdomain Microbial Network Underpins Cadaver Decomposition despite Environmental Variables
Microbial breakdown of organic matter is one of the most important processes on Earth, yet the controls of decomposition are poorly …
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Partial Order Relation–Based Gene Ontology Embedding Improves Protein Function Prediction
Protein annotation has long been a challenging task in computational biology. Gene Ontology (GO) has become one of the most popular …
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DeepPhylo: Phylogeny-Aware Microbial Embeddings Enhanced Predictive Accuracy in Human Microbiome Data Analysis
Microbial data analysis poses significant challenges due to its high dimensionality, sparsity, and compositionality. Recent advances …
Bin Wang, Yulong Shen, Jingyan Fang, Xiaoquan Su, Zhenjiang Zech Xu
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Meta-Analysis Reveals Helicobacter Pylori Mutual Exclusivity and Reproducible Gastric Microbiome Alterations during Gastric Carcinoma Progression
Accumulating evidence shows that the gastric bacterial community may contribute to the development of gastric cancer (GC). However, the …
Yan Li, Yichen Hu, Xiang Zhan, Ying Song, Meng Xu, Shijie Wang, Xiaochang Huang, Zhenjiang Zech Xu
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Paired Microbiome and Metabolome Analyses Associate Bile Acid Changes with Colorectal Cancer Progression
Colorectal cancer (CRC) is driven by genomic alterations in concert with dietary influences, with the gut microbiome implicated as an …
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Effects of Vaginal Microbiota Transfer on the Neurodevelopment and Microbiome of Cesarean-Born Infants: A Blinded Randomized Controlled Trial
The microbiomes of cesarean-born infants differ from vaginally delivered infants and are associated with increased disease risks. …
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